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PHD activates the pseudohypoxic response by stabilizing HIF-1, which is a well-known tumorigenesis enhancer, and as a transcription factor, maintains the metabolic reprogramming of cancer cells to support their survival 127

Infections Tick-borne infections like Lyme disease, viral infections like Epstein-Barr, or gut infections like SIBO may cause Hashimotos thyroiditis

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In addition, CLOCK/BMAL1 was responsible for the transactivation of the hGH gene promotor